The antihypertensive effect is substantially existing inside two weeks and maximal reduction is typically attained following four weeks. If added antihypertensive impact is essential, the dosage may possibly be elevated to 160 mg or 320 mg or a diuretic may be extra. Addition of a diuretic has a greater result than dose boosts beyond 80 mg.
No original dosage adjustment is required for elderly individuals, for patients with gentle or reasonable renal impairment, or for individuals with mod
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